Social CBD Oil Tincture Drops and migraines. Migraines are recurrent headaches that are moderate to severe in nature, and typically cause pulsating pain that often happens on one side of the head. They can last from hours to days, and are often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. They can be completely debilitating. Migraine sufferers also tend to experience depression, anxiety, and sleep problems. The exact causes are not known, but migraines may be caused by changes in the brainstem and its interactions with the trigeminal nerve, a major pain pathway.

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Imbalances in brain chemicals including serotonin, which helps to regulate pain in your nervous system may also be involved. Researchers are still studying the role of serotonin in migraines, but serotonin levels in the brain drop during migraines. Migraines may be triggered by a variety of other factors, like hormonal changes, foods, food additives, drinks like coffee and alcohol, stress, and changes in sleep habits.

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Recent studies are supporting a link between endocannabinoid system deficiency and migraines.96 Russo’s own work studying the use of cannabinoids for migraine treatment supports this theory. More recently, work done by researchers posits that triggers (mentioned above) initiate a chemical reaction in the brain, one that would normally stimulate the release of endogenous cannabinoids to restore balance. For reasons still unknown, migraine sufferers may not produce endogenous cannabinoids in the face of these triggers. This leads to a cascade of pain-inducing signals within the brain, which causes a dilation of blood vessels and an increase in pressure and swelling.

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In a recent study in human patients, results showed that THC and CBD in combination was an effective form of pain relief in high dosages (200 milligrams total). In the second phase of this study, some patients were prescribed 25 milligrams of Amitriptyline, an antidepressant commonly used for migraines, or 200 milligrams of the THC/CBD combination. After three months of use, it was shown that the THC/CBD medicine was most effective in treating acute pain during an attack, as opposed to decreasing the frequency or duration of attacks.

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Inflammatory diseases like Crohn’s, and syndromes like IBS, cause inflammation of the inner lining of the colon. This inflammation can lead to lots of painful symptoms like cramping, bloating, diarrhea, gas, and constipation. Luckily, there is an abundance of cannabinoid receptors, particularly CB2, in the gut. Because CBD interacts with the CB2 receptors, it’s got great potential for treating these conditions.

There have been several studies over the last decade or so showing a strong link between the endocannabinoid system and the GI system.89 A 2016 study showed that CBD might suppress colitis by reducing the activation of T-cells and inflammatory response in the colon. CBD has also been shown to reduce hypermotility (abnormally high activity) in the guts of mice. CBD’s ability to interact with other receptors outside the endocannabinoid system (specifically the PPAR-gamma) also makes it a novel candidate for treating inflammatory bowel disease (IBD).

In one 2011 study, colitis was induced in rodents and the results showed that THC was somewhat effective on its own while CBD was not.93 A lower dose of THC combined with CBD proved most effective, giving more support for the synergistic relationship between the two and the theory of the entourage effect. The combination of THC and CBD also improved colonic muscle movement. Another 2011 animal study showed that administering CBD after inflammation was induced reduced the inflammation, while administering it before the inflammation was induced prevented it from happening at all.

In fact, many professionals believe there is a strong connection between the ECS and gut. Dr. Ethan Russo believes that deficiencies in the endocannabinoid system can cause a variety of conditions, including IBS.